Răileanu I, Rusu V, Stefănescu C, Cinotti L
Facultatea de Medicină Disciplina de Biofizică şi Medicină Nucleară, Universitatea de Medicină şi Farmacie Gr. T. Popa Iaşi.
Rev Med Chir Soc Med Nat Iasi. 2001 Oct-Dec;105(4):638-45.
The greatest branch of evolution in Nuclear Medicine that appear in the last period of time, also in medical practice, is scintigraphy with 18F FDG-PET. At the beginning, the images with 18F FDG were used especially in the study of functional cerebral metabolism. Now, new data show that the method presents en major role in cancer diagnosis, localize the tumour and metastasis, and monitoring the treatment in oncology because of the peculiars changes in glucose metabolism of the cancer cells. In this two parts of reference synthesis our goal was to present the following subjects: I) first part include the particularities of glucose metabolism of tumour cells, functionality and components of PET, radiopharmaceutical used in PET, the synthesis of 18F FDG, the clinical procedure and the detection of unknown cancers; II) the second part is about the mains types of tumours identified with 18F FDG-PET (lung, breast, lymphoma, melanoma, colorectal cancer and others). The clinical cases that illustrate the applications are investigated at CERMEP, Lyon, France.
核医学领域近年来在医学实践中出现的最大进展分支是18F FDG-PET闪烁扫描术。起初，18F FDG图像尤其用于功能性脑代谢研究。现在，新数据表明，由于癌细胞葡萄糖代谢的特殊变化，该方法在癌症诊断、肿瘤及转移灶定位以及肿瘤学治疗监测中发挥着重要作用。在本参考文献综述的这两部分中，我们的目标是呈现以下主题：I）第一部分包括肿瘤细胞葡萄糖代谢的特点、PET的功能及组成部分、PET中使用的放射性药物、18F FDG的合成、临床程序以及未知癌症的检测；II）第二部分是关于用18F FDG-PET识别的主要肿瘤类型（肺癌、乳腺癌、淋巴瘤、黑色素瘤、结直肠癌等）。法国里昂的CERMEP对说明这些应用的临床病例进行了研究。
