Meuret G, Tschan P
Schweiz Med Wochenschr. 1975 Nov 22;105(47):1580-1.
The relative DNA, RNA histone and hemoglobin contents and 3H-thymidine incorporation in vitro were determined sequentially in individual erythroblasts of type I dyserythropoietic anemia. The histone/DNA ratio was increased due to a rise in histone extinction, indicating a pathological DNA-nucleoprotein complex. In addition, the erythroblasts displayed an increase in DNA content exceeding tetraploid values, a loss of DNA-synthesis activity at immature stages with low hemoglobin content, and a reduction of RNA. These variations were assumed to be caused by the preceding and primary impairment of the DNA-nucleoprotein complex.
对I型异常红细胞生成性贫血的单个成红细胞依次测定其相对DNA、RNA、组蛋白和血红蛋白含量以及体外3H-胸腺嘧啶核苷掺入情况。由于组蛋白消光增加，组蛋白/DNA比值升高，表明存在病理性DNA-核蛋白复合体。此外，成红细胞显示DNA含量增加超过四倍体值，在血红蛋白含量低的未成熟阶段DNA合成活性丧失，以及RNA减少。这些变化被认为是由DNA-核蛋白复合体先前的原发性损伤引起的。
