Versmold H, Riegel K, Betke K
Schweiz Med Wochenschr. 1975 Nov 22;105(47):1592-3.
In 107 infants aged 3 hours to 9 months, hemoglobin concentration, 2,3-DPG concentration and GOT activity in red cells, and reticulocyte count were determined in order to evaluate whether the previously observed decrease in red cell 2,3-DPG [1] during the first 30-40 days of life related to red cell ageing. A significant positive correlation of 2,3-DPG vs. GOT, an indicator of red cell age, is found. The decrease in 2,3-DPG over a period of 25-30 days is finally followed by a sharp rise in reticulocyte count, suggesting that an alteration in blood oxygen affinity might trigger the onset of erythropoiesis in normal infants in this age group.
为评估之前观察到的出生后30 - 40天内红细胞2,3 - 二磷酸甘油酸（2,3-DPG）[1]的减少是否与红细胞衰老有关，对107名年龄在3小时至9个月的婴儿进行了红细胞血红蛋白浓度、2,3-DPG浓度、谷草转氨酶（GOT）活性以及网织红细胞计数的测定。研究发现，红细胞年龄指标GOT与2,3-DPG之间存在显著正相关。在25 - 30天内2,3-DPG下降，最终伴随网织红细胞计数急剧上升，这表明血氧亲和力的改变可能触发该年龄组正常婴儿的红细胞生成。
