Baxter Alan G, Hodgkin Philip D
Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia.
Nat Rev Immunol. 2002 Jun;2(6):439-46. doi: 10.1038/nri823.
Two-signal theories of lymphocyte activation have evolved considerably over the past 35 years. In this article, we examine the contemporary experimental observations and theoretical concerns that have helped to forge the most influential variants of the theory. We also propose that more-rigorous quantitative methods are required to sustain theoretical development in the future.
在过去35年里，淋巴细胞激活的双信号理论有了相当大的发展。在本文中，我们审视了当代的实验观察结果以及理论关注点，这些因素推动形成了该理论最具影响力的变体。我们还提出，未来需要更严谨的定量方法来维持理论发展。
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