Liberles David A, Wayne Marta L
Department of Biochemistry and Biophysics and Stockholm Bioinformatics Center, Stockholm University, 10691 Stockholm, Sweden.
Genome Biol. 2002;3(6):REVIEWS1018. doi: 10.1186/gb-2002-3-6-reviews1018. Epub 2002 May 29.
As more gene and genomic sequences from an increasing assortment of species become available, new pictures of evolution are emerging. Improved methods can pinpoint where positive and negative selection act in individual codons in specific genes on specific branches of phylogenetic trees. Positive selection appears to be important in the interaction between genotype, protein structure, function, and organismal phenotype.
随着越来越多来自各种物种的基因和基因组序列可供使用，新的进化图景正在浮现。改进后的方法能够精确指出正选择和负选择在系统发育树特定分支上特定基因的单个密码子中发挥作用的位置。正选择在基因型、蛋白质结构、功能和生物体表型之间的相互作用中似乎起着重要作用。
