Chan Sue-Joan, Chang Chen-Nen, Hsu Jee-Ching, Lee Ying-Shiung, Shen Chen-Hsiang
Department of Biology, National Cheng Kung University, Tainan, Taiwan 701, R.O.C.
Nutrition. 2002 Jul-Aug;18(7-8):595-8. doi: 10.1016/s0899-9007(02)00778-5.
Elevated homocysteine (Hcy) is considered an independent risk factor for cardiovascular disease (CVD). An elevated plasma Hcy level may interact with conventional CVD risk factors to further increase vascular disease risk. Therefore, we investigated the plasma levels of Hcy, vitamin B(6) status (pyridoxal phosphate and pyridoxal), and lipid profile in patients with CVD.
Possible associations between sex, age, body mass index (BMI), and waist-to-hip ratio (WHR) to levels of plasma Hcy and plasma Hcy to vitamin B(6) status and lipid profile were examined.
Plasma Hcy level, body mass index, and waist-to-hip ratio were significantly higher in patients with CVD than in controls. Male CVD patients had significantly higher plasma Hcy levels than did female patients. Plasma levels of pyridoxal phosphate and total B(6) aldehyde were significantly higher in male than in female patients. Plasma Hcy levels of patients did not correlate to their plasma vitamin B(6) status or to their lipid profiles. Plasma Hcy level correlated positively with age, body mass index, and waist-to-hip ratio (P < 0.0001).
This suggested that patients with CVD have higher levels of plasma Hcy that are influenced by sex, age, body mass index, and waist-to-hip ratio and not by their plasma vitamin B(6) status and lipid profiles.
高同型半胱氨酸（Hcy）被认为是心血管疾病（CVD）的一个独立危险因素。血浆Hcy水平升高可能与传统的CVD危险因素相互作用，进一步增加血管疾病风险。因此，我们研究了CVD患者的血浆Hcy水平、维生素B6状态（磷酸吡哆醛和吡哆醛）及血脂谱。
研究了性别、年龄、体重指数（BMI）和腰臀比（WHR）与血浆Hcy水平之间可能存在的关联，以及血浆Hcy与维生素B6状态和血脂谱之间的关联。
CVD患者的血浆Hcy水平、体重指数和腰臀比显著高于对照组。男性CVD患者的血浆Hcy水平显著高于女性患者。男性患者的磷酸吡哆醛和总B6醛的血浆水平显著高于女性患者。患者的血浆Hcy水平与其血浆维生素B6状态或血脂谱无关。血浆Hcy水平与年龄、体重指数和腰臀比呈正相关（P < 0.0001）。
这表明CVD患者的血浆Hcy水平较高，其受性别、年龄、体重指数和腰臀比影响，而非受血浆维生素B6状态和血脂谱影响。
