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对母体环境进行干预可逆转具有遗传易感性大鼠的牙周炎。

Manipulations in maternal environment reverse periodontitis in genetically predisposed rats.

作者信息

Sluyter Frans, Breivik Torbjørn, Cools Alexander

机构信息

SGDP Research Centre, Institute of Psychiatry, London, United Kingdom.

出版信息

Clin Diagn Lab Immunol. 2002 Jul;9(4):931-2. doi: 10.1128/cdli.9.4.931-932.2002.

DOI:10.1128/cdli.9.4.931-932.2002
PMID:12093700
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC120013/
Abstract

The predisposition to develop periodontitis is partly genetically determined in humans as well as in animals. Here we demonstrate, however, that early manipulations in the maternal environment of an animal (rat) model of periodontitis can fully reverse the genetic predisposition to develop periodontitis at adult age.

摘要

人类和动物患牙周炎的易感性部分由基因决定。然而，我们在此证明，在牙周炎动物（大鼠）模型的母体环境中进行早期干预，可以完全逆转成年后患牙周炎的遗传易感性。

相似文献

1
Manipulations in maternal environment reverse periodontitis in genetically predisposed rats.对母体环境进行干预可逆转具有遗传易感性大鼠的牙周炎。
Clin Diagn Lab Immunol. 2002 Jul;9(4):931-2. doi: 10.1128/cdli.9.4.931-932.2002.
2
[Genetics and periodontitis].
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The pathobiology of periodontal diseases may affect systemic diseases: inversion of a paradigm.牙周疾病的病理生物学可能影响全身疾病：一种范式的转变。
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[Periodontitis is one of the most commonly occurring inflammatory diseases].牙周炎是最常见的炎症性疾病之一。
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Modifiable risk factors in periodontitis: at the intersection of aging and disease.可改变的牙周炎风险因素：在衰老和疾病的交叉点。
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引用本文的文献

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Microbiota-immune-brain interactions: A new vision in the understanding of periodontal health and disease.微生物群-免疫-大脑相互作用：理解牙周健康和疾病的新视角。
Periodontol 2000. 2024 Oct;96(1):20-41. doi: 10.1111/prd.12610. Epub 2024 Sep 4.
2
Maternal Deprivation of Lewis Rat Pups Increases the Severity of Experi-mental Periodontitis in Adulthood.对Lewis大鼠幼崽进行母婴分离会增加成年后实验性牙周炎的严重程度。
Open Dent J. 2015 Jan 30;9:65-78. doi: 10.2174/1874210601509010065. eCollection 2015.

本文引用的文献

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Maternal deprivation of rat pups increases clinical symptoms of experimental autoimmune encephalomyelitis at adult age.
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Apomorphine-susceptible and apomorphine-unsusceptible Wistar rats differ in their susceptibility to inflammatory and infectious diseases: a study on rats with group-specific differences in structure and reactivity of hypothalamic-pituitary-adrenal axis.对阿扑吗啡敏感和不敏感的Wistar大鼠在对炎症和感染性疾病的易感性方面存在差异：一项关于下丘脑-垂体-肾上腺轴结构和反应性具有组特异性差异的大鼠的研究。
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9
Relevance of local Th2-type cytokine mRNA expression in immunocompetent infiltrates in inflamed gingival tissue to periodontal diseases.炎症牙龈组织中免疫活性浸润物中局部Th2型细胞因子mRNA表达与牙周疾病的相关性。
Clin Exp Immunol. 1997 Jan;107(1):166-74. doi: 10.1046/j.1365-2249.1997.d01-880.x.
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Cellular immunity and hypersensitivity as components of periodontal destruction.细胞免疫和超敏反应作为牙周组织破坏的组成部分。
Oral Dis. 1996 Mar;2(1):96-101. doi: 10.1111/j.1601-0825.1996.tb00209.x.