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Strategies for an HIV vaccine.艾滋病病毒疫苗的策略。
J Clin Invest. 2002 Jul;110(1):15-20. doi: 10.1172/JCI15985.
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A review of vaccine research and development: the human immunodeficiency virus (HIV).疫苗研发综述：人类免疫缺陷病毒（HIV）
Vaccine. 2006 May 8;24(19):4062-81. doi: 10.1016/j.vaccine.2006.02.031. Epub 2006 Feb 28.
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HIV vaccine development: lessons learned to date.
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The Maginot Line and AIDS vaccines.
Med Hypotheses. 1997 Jun;48(6):527-9. doi: 10.1016/s0306-9877(97)90124-9.
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Vaccines for the prevention of HIV-1 disease.
Curr Opin Immunol. 2001 Aug;13(4):489-95. doi: 10.1016/s0952-7915(00)00246-6.
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Infectious disease. An enterprising time for HIV vaccine research.传染病。艾滋病病毒疫苗研究的进取时代。
Science. 2012 Sep 21;337(6101):1446. doi: 10.1126/science.337.6101.1446.
7
Prospects for vaccine protection against HIV-1 infection and AIDS.预防HIV-1感染和艾滋病的疫苗保护前景。
Annu Rev Immunol. 2002;20:73-99. doi: 10.1146/annurev.immunol.20.081501.094854. Epub 2001 Oct 4.
8
The 2017 Keystone Symposium on HIV Vaccines.2017年艾滋病疫苗关键研讨会
Hum Vaccin Immunother. 2017 Oct 3;13(10):2348-2351. doi: 10.1080/21645515.2017.1353852.
9
New mouse models provide insights into how to design a more effective HIV vaccine.
AIDS. 2017 Jan 28;31(3):N3-N4. doi: 10.1097/QAD.0000000000001371.
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Use of synthetic peptides in primates to induce high-titered neutralizing antibodies and MHC class I-restricted cytotoxic T cells against acquired immunodeficiency syndrome retroviruses: an HLA-based vaccine strategy.
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HIV vaccination: Navigating the path to a transformative breakthrough-A review of current evidence.HIV疫苗接种：探寻变革性突破之路——当前证据综述
Health Sci Rep. 2024 Sep 23;7(9):e70089. doi: 10.1002/hsr2.70089. eCollection 2024 Sep.
2
Development of a Live Recombinant BCG Expressing Human Immunodeficiency Virus Type 1 (HIV-1) Gag Using a pMyong2 Vector System: Potential Use As a Novel HIV-1 Vaccine.使用 pMyong2 载体系统构建表达人类免疫缺陷病毒 1 型（HIV-1）Gag 的活重组卡介苗：作为新型 HIV-1 疫苗的潜在用途。
Front Immunol. 2018 Mar 27;9:643. doi: 10.3389/fimmu.2018.00643. eCollection 2018.
3
Recombinant Mycobacterium smegmatis with a pMyong2 vector expressing Human Immunodeficiency Virus Type I Gag can induce enhanced virus-specific immune responses.携带有表达人类免疫缺陷病毒 I 型 Gag 的 pMyong2 载体的重组耻垢分枝杆菌可以诱导增强的病毒特异性免疫反应。
Sci Rep. 2017 Mar 16;7:44776. doi: 10.1038/srep44776.
4
Current Advances in Virus-Like Particles as a Vaccination Approach against HIV Infection.病毒样颗粒作为一种预防 HIV 感染的疫苗接种方法的最新进展。
Vaccines (Basel). 2016 Jan 22;4(1):2. doi: 10.3390/vaccines4010002.
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Comparison of Immunogenicity in Rhesus Macaques of Transmitted-Founder, HIV-1 Group M Consensus, and Trivalent Mosaic Envelope Vaccines Formulated as a DNA Prime, NYVAC, and Envelope Protein Boost.作为DNA初免、NYVAC和包膜蛋白加强免疫方案的传播奠基者型、HIV-1 M组共识型和三价嵌合包膜疫苗在恒河猴中的免疫原性比较。
J Virol. 2015 Jun;89(12):6462-80. doi: 10.1128/JVI.00383-15. Epub 2015 Apr 8.
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Bovine papillomavirus-like particles presenting conserved epitopes from membrane-proximal external region of HIV-1 gp41 induced mucosal and systemic antibodies.牛乳头瘤病毒样颗粒展示了 HIV-1 gp41 膜近端外部区域的保守表位，诱导了黏膜和系统抗体。
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Vaccine. 2012 Dec 14;30(52):7547-60. doi: 10.1016/j.vaccine.2012.10.042. Epub 2012 Oct 24.
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Priming with a recombinant pantothenate auxotroph of Mycobacterium bovis BCG and boosting with MVA elicits HIV-1 Gag specific CD8+ T cells.用重组泛酸营养缺陷型牛分枝杆菌卡介苗（BCG）进行初始免疫，并用 MVA 进行加强免疫，可引发 HIV-1 Gag 特异性 CD8+ T 细胞。
PLoS One. 2012;7(3):e32769. doi: 10.1371/journal.pone.0032769. Epub 2012 Mar 29.
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Newborn mice vaccination with BCG.HIVA²²² + MVA.HIVA enhances HIV-1-specific immune responses: influence of age and immunization routes.用卡介苗. HIVA²²² + 痘苗病毒载体疫苗. HIVA对新生小鼠进行疫苗接种可增强HIV-1特异性免疫反应：年龄和免疫途径的影响
Clin Dev Immunol. 2011;2011:516219. doi: 10.1155/2011/516219. Epub 2011 Apr 12.
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Molecular characterization of heterologous HIV-1gp120 gene expression disruption in mycobacterium bovis BCG host strain: a critical issue for engineering mycobacterial based-vaccine vectors.牛分枝杆菌卡介苗宿主菌株中异源HIV-1 gp120基因表达破坏的分子特征：基于分枝杆菌的疫苗载体工程的关键问题。
J Biomed Biotechnol. 2010;2010:357370. doi: 10.1155/2010/357370. Epub 2010 Jun 27.

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Strategies for an HIV vaccine.

作者信息

Letvin Norman L

机构信息

Harvard Medical School, Beth Israel Deaconess Medical Center, 41 Avenue Louis Pasteur, RE-113, Boston, MA 02215, USA.

出版信息

J Clin Invest. 2002 Jul;110(1):15-20. doi: 10.1172/JCI15985.

DOI:10.1172/JCI15985
PMID:12093882
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC151036/
Abstract
摘要