Live-attenuated virus vaccines for respiratory syncytial and parainfluenza viruses: applications of reverse genetics.
作者信息
Murphy Brian R, Collins Peter L
机构信息
Respiratory Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases/NIH, Building 50, Room 6517, 50 South Drive MSC 8007, Bethesda, MD 20892, USA.
出版信息
J Clin Invest. 2002 Jul;110(1):21-7. doi: 10.1172/JCI16077.
Abstract
摘要
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本文引用的文献
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Sequence analysis of the Washington/1964 strain of human parainfluenza virus type 1 (HPIV1) and recovery and characterization of wild-type recombinant HPIV1 produced by reverse genetics.1型人副流感病毒（HPIV1）华盛顿/1964株的序列分析以及通过反向遗传学产生的野生型重组HPIV1的恢复与特性鉴定。
Virus Genes. 2002;24(1):77-92. doi: 10.1023/a:1014042221888.
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A newly discovered human pneumovirus isolated from young children with respiratory tract disease.从患有呼吸道疾病的幼儿中分离出的一种新发现的人类肺炎病毒。
Nat Med. 2001 Jun;7(6):719-24. doi: 10.1038/89098.
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Recovery of infectious human parainfluenza type 2 virus from cDNA clones and properties of the defective virus without V-specific cysteine-rich domain.从互补DNA克隆中恢复感染性人副流感病毒2型以及不含V特异性富含半胱氨酸结构域的缺陷病毒的特性
Virology. 2001 May 25;284(1):99-112. doi: 10.1006/viro.2001.0864.
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Expression of the surface glycoproteins of human parainfluenza virus type 3 by bovine parainfluenza virus type 3, a novel attenuated virus vaccine vector.新型减毒病毒疫苗载体——牛副流感病毒3型表达人副流感病毒3型的表面糖蛋白
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Recombinant respiratory syncytial virus that does not express the NS1 or M2-2 protein is highly attenuated and immunogenic in chimpanzees.不表达NS1或M2-2蛋白的重组呼吸道合胞病毒在黑猩猩中高度减毒且具有免疫原性。
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Bovine parainfluenza virus type 3 (BPIV3) fusion and hemagglutinin-neuraminidase glycoproteins make an important contribution to the restricted replication of BPIV3 in primates.牛副流感病毒3型（BPIV3）融合糖蛋白和血凝素-神经氨酸酶糖蛋白对BPIV3在灵长类动物中的限制性复制起重要作用。
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Recombinant respiratory syncytial viruses with deletions in the NS1, NS2, SH, and M2-2 genes are attenuated in vitro and in vivo.在NS1、NS2、SH和M2-2基因中存在缺失的重组呼吸道合胞病毒在体外和体内均表现出减毒特性。
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Long nucleotide insertions between the HN and L protein coding regions of human parainfluenza virus type 3 yield viruses with temperature-sensitive and attenuation phenotypes.人副流感病毒3型的血凝素神经氨酸酶（HN）和融合蛋白（F）编码区之间的长核苷酸插入产生具有温度敏感性和减毒表型的病毒。 （注：原文中是HN和L，推测此处应为HN和F，否则表述与专业知识不符，以上译文按正确内容翻译。若严格按原文则是：人副流感病毒3型的血凝素神经氨酸酶（HN）和L蛋白编码区之间的长核苷酸插入产生具有温度敏感性和减毒表型的病毒。）
Virology. 2000 Jun 20;272(1):225-34. doi: 10.1006/viro.2000.0372.
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A recombinant human parainfluenza virus type 3 (PIV3) in which the nucleocapsid N protein has been replaced by that of bovine PIV3 is attenuated in primates.一种重组人3型副流感病毒（PIV3），其中核衣壳N蛋白已被牛PIV3的核衣壳N蛋白所取代，在灵长类动物中具有减毒作用。
J Virol. 2000 Apr;74(7):3188-95. doi: 10.1128/jvi.74.7.3188-3195.2000.
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