Chuansumrit Ampaiwan, Nuntnarumit Pracha, Okascharoen Chusak, Teeraratkul Sumete, Suwansingh Saranya, Supapannachart Sarayut
Department of Pediatrics, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Pediatrics. 2002 Jul;110(1 Pt 1):169-71. doi: 10.1542/peds.110.1.169.
The case of a preterm infant weighing 1120 g who successfully received recombinant activated factor VII (rFVIIa) without complication for control of a life-threatening bleeding event resulting from a ruptured umbilical artery is reported. After performing an exploratory laparotomy at 27 hours of age, hemorrhage from the surgical wound and various sites persisted. By 63 hours of age, the infant had received a total of 192 mL (171 mL/kg) of packed red blood cells, 115 mL (103 mL/kg) of fresh frozen plasma, 8 mL of cryoprecipitate, and 75 mL (67 mL/kg) of platelet concentrate without stabilization. Hemorrhage ceased after 2 doses of 40 microg/kg/dose recombinant activated factor VII given at 63 and 70 hours of age, with subsequent stabilization of the hematocrit and without need for additional transfusion therapy.
报告了一例体重1120克的早产儿，其成功接受重组活化因子VII（rFVIIa）且无并发症，以控制因脐动脉破裂导致的危及生命的出血事件。在27小时龄进行剖腹探查术后，手术伤口和其他部位持续出血。到63小时龄时，该婴儿共接受了192毫升（171毫升/千克）的浓缩红细胞、115毫升（103毫升/千克）的新鲜冰冻血浆、8毫升冷沉淀和75毫升（67毫升/千克）的血小板浓缩液，但出血仍未得到控制。在63小时龄和70小时龄分别给予2剂40微克/千克剂量的重组活化因子VII后出血停止，随后血细胞比容稳定，无需额外的输血治疗。
