Ben-Ezra Jonathan
Department of Pathology, Medical College of Virginia, Hospitals of Virginia Commonwealth University, POB 980250, Richmond, VA 23298, USA.
Hematol Oncol Clin North Am. 2002 Apr;16(2):321-37. doi: 10.1016/s0889-8588(02)00007-2.
The differential diagnosis of the B-cell lymphoproliferative disorders can sometimes by tricky. When the morphology and flow cytometric studies are classic, the case should not present a diagnostic challenge. However, when the lesion does not read the book, one must take into consideration the morphology/cytology, flow cytometry, and clinical history. Integrating all three of these will often lead to the correct diagnosis; however, there will be occasional cases where the best that a pathologist can say is "B-cell lymphoproliferative disorder". In those instances, one should not overcall something, but rather should state what the problems are, and what are most likely to be the diagnostic possibilities.
B 细胞淋巴增殖性疾病的鉴别诊断有时颇具挑战性。当形态学和流式细胞术研究结果典型时，该病例不应构成诊断难题。然而，当病变不典型时，必须综合考虑形态学/细胞学、流式细胞术及临床病史。整合这三个方面通常会得出正确诊断；不过，偶尔也会出现病理学家只能诊断为“B 细胞淋巴增殖性疾病”的情况。在这些情况下，不应过度诊断，而应说明存在的问题以及最有可能的诊断可能性。
