NM23和腱生蛋白在乳腺浸润性导管癌中的表达。
Expression of NM23 and tenascin in invasive ductal carcinomas of the breast.
作者信息
Kaya H, Hücümenoğlu S, Bozkurt S U, Ekicioğlu G, Kotiloğlu E
机构信息
Marmara University Hospital, Pathology Department, Istanbul, Turkey.
出版信息
Eur J Gynaecol Oncol. 2002;23(3):261-3.
OBJECTIVE
In this series of ductal carcinoma of the breast, immunoexpression of antimetastasis gene nm23 and tenascin was examined and the role in prognosis was investigated by correlation with the tumour grade and stage, and ER/PR immunoexpression.
MATERIAL AND METHODS
In this study 27 ductal carcinomas of the breast were analysed for expression of tenascin and nm23 antimetastasis genes by immunohistochemistry.
RESULTS
The results of our study revealed a statistically significant correlation between nm23-H1 immunoexpression and lymph node metastasis. We also found a statistically significant correlation between tenascin and nm23-H1 immunoexpression. Our results suggest that tenascin limits tumour spread.
CONCLUSION(S): Antimetastasis gene expression can be used in predicting lymph node metastasis in ductal carcinomas of the breast.
目的
在这一系列乳腺癌中，检测抗转移基因nm23和腱生蛋白的免疫表达，并通过与肿瘤分级、分期以及雌激素受体/孕激素受体免疫表达的相关性研究其在预后中的作用。
材料与方法
本研究采用免疫组织化学方法分析了27例乳腺癌中腱生蛋白和nm23抗转移基因的表达。
结果
我们的研究结果显示nm23-H1免疫表达与淋巴结转移之间存在统计学上的显著相关性。我们还发现腱生蛋白与nm23-H1免疫表达之间存在统计学上的显著相关性。我们的结果表明腱生蛋白限制肿瘤扩散。
结论
抗转移基因表达可用于预测乳腺癌的淋巴结转移。
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