Suzuki Rie, Dickenson Anthony H
Department of Pharmacology, University College London, Gower Street, London, WC1E 6BT, United Kingdom.
Curr Pain Headache Rep. 2002 Aug;6(4):267-73. doi: 10.1007/s11916-002-0047-0.
Chronic widespread pain is a primary feature of fibromyalgia and is a symptom that is poorly managed in many patients. In addition, patients often experience fatigue, sleep disturbances, and anxiety. Its etiology is largely unknown. The successful clinical management of this syndrome relies on a multidisciplinary approach, employing pharmacologic and nonpharmacologic treatments. Clinical evidence on the symptoms and characteristics of fibromyalgia suggests a central mechanism behind the pathogenesis of this syndrome. It is likely that drugs with central actions will prove to be effective against a number of symptoms. This article aims to outline some of the potential spinal pharmacologic targets that may be used to treat this condition.
慢性广泛性疼痛是纤维肌痛的主要特征，也是许多患者管理不善的症状。此外，患者常伴有疲劳、睡眠障碍和焦虑。其病因很大程度上尚不清楚。该综合征的成功临床管理依赖于多学科方法，采用药物和非药物治疗。关于纤维肌痛症状和特征的临床证据表明，该综合征发病机制背后存在中枢机制。具有中枢作用的药物可能对多种症状有效。本文旨在概述一些可能用于治疗该病症的潜在脊髓药理学靶点。
