Green Mark G, Scarth Julia, Dickenson Anthony
Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK.
Pain. 2000 Dec 15;89(1):81-88. doi: 10.1016/S0304-3959(00)00346-8.
The involvement of 5-HT(3) receptor mediated modulation of formalin and carrageenan induced inflammatory transmission was investigated. The effects of the selective 5-HT(3) receptor antagonist ondansetron on the electrically evoked responses of dorsal horn neurones in normal animals were compared to those following carrageenan. The effect of pre-treatment on the formalin response was also studied. Ondansetron had no significant effect on the electrically evoked responses of dorsal horn neurones in normal animals or following carrageenan induced inflammation, but significantly inhibited both phases of the formalin response. Our results suggest that 5-HT(3) receptors in the spinal cord have no significant role under normal conditions. However, during formalin (but not carrageenan) induced inflammation this system is activated, maintaining the response of nociceptive spinal neurones to peripheral formalin.
研究了5-羟色胺（5-HT）(3)受体介导的对福尔马林和角叉菜胶诱导的炎症传递的调节作用。将选择性5-HT(3)受体拮抗剂昂丹司琼对正常动物背角神经元电诱发反应的影响与角叉菜胶处理后的影响进行了比较。还研究了预处理对福尔马林反应的影响。昂丹司琼对正常动物或角叉菜胶诱导炎症后的背角神经元电诱发反应无显著影响，但显著抑制了福尔马林反应的两个阶段。我们的结果表明，脊髓中的5-HT(3)受体在正常条件下无显著作用。然而，在福尔马林（而非角叉菜胶）诱导的炎症过程中，该系统被激活，维持伤害性脊髓神经元对外周福尔马林的反应。
