Morton W A, Parmentier E M, Petschek H E
Thromb Diath Haemorrh. 1975 Dec 15;34(3):840-54.
The formation of platelet aggregates which embolize to the peripheral circulation has previously been noted as a significant deleterious effect resulting from both intra- and extracorporeal artificial circulatory devices. Utilizing the stagnation point flow experiment, which permits visualization during flow of aggregate formation on first contact of blood with an artificial surface, the formation of freely floating aggregates has been observed in separated flow regions. Embolization from the separated flow has also been noted. Comparison of observed growth rates with a hydrodynamic model suggests that sufficient activation has occurred within the separated region so that platelets stick on virtually every collision. Some criteria are also suggested which correlate with the flow conditions affecting aggregate formation. At high flow rates, where freely floating aggregates do not form, significant surface thrombi are found.
血小板聚集体形成并栓塞至外周循环，此前已被视为体内和体外人工循环装置产生的一种显著有害效应。利用驻点流动实验，该实验可在血液首次接触人工表面时观察聚集体形成过程中的流动情况，已在分离流动区域观察到自由漂浮聚集体的形成。还注意到有栓子从分离流动区域栓塞。将观察到的生长速率与流体动力学模型进行比较表明，在分离区域内已发生足够的激活，以至于血小板几乎每次碰撞都会黏附。还提出了一些与影响聚集体形成的流动条件相关的标准。在高流速下，不会形成自由漂浮聚集体，但会发现大量表面血栓。
