Pola Roberto, Flex Andrea, Gaetani Eleonora, Papaleo Pierangelo, De Martini Demetrio, Gerardino Laura, Serricchio Michele, Pola Paolo, Bernabei Roberto
Laboratory of Vascular Biology and Genetics, A. Gemelli University Hospital, Università Cattolica del Sacro Cuore School of Medicine, Rome, Italy.
Neurosci Lett. 2002 Jul 5;326(3):171-4. doi: 10.1016/s0304-3940(02)00337-3.
Intercellular adhesion molecule-1 (ICAM-1) is implicated in the pathogenesis of ischemic cardiovascular disorders, including cerebral ischemia. A common polymorphism of the ICAM-1 gene (K469E) has been recently reported. In this case-control study, we evaluated the association between this polymorphism and vascular dementia (VD) by studying 107 patients affected by probable VD and 115 age- and sex-matched controls. The frequency of the EE genotype was significantly higher in VD patients than controls (P=0.009). Logistic regression analysis indicated that the presence of the EE genotype significantly increased the risk of VD (odds ratio 3.25, P=0.024). Our findings support the hypothesis that ICAM-1 plays a role in the physiopathology of ischemic cerebrovascular disorders and suggest that genetic polymorphisms of ICAM-1 might be clinically important in the development and progression of neurodegenerative diseases.
细胞间黏附分子-1（ICAM-1）与包括脑缺血在内的缺血性心血管疾病的发病机制有关。最近报道了ICAM-1基因的一种常见多态性（K469E）。在这项病例对照研究中，我们通过研究107例可能患有血管性痴呆（VD）的患者和115例年龄及性别匹配的对照，评估了这种多态性与血管性痴呆之间的关联。VD患者中EE基因型的频率显著高于对照组（P=0.009）。逻辑回归分析表明，EE基因型的存在显著增加了VD的风险（优势比3.25，P=0.024）。我们的研究结果支持ICAM-1在缺血性脑血管疾病的病理生理学中起作用这一假说，并表明ICAM-1的基因多态性在神经退行性疾病的发生和发展中可能具有重要临床意义。
