1型菌毛大肠杆菌对小鼠膀胱组织中细胞因子的诱导作用

Cytokine induction in murine bladder tissue by type 1 fimbriated Escherichia coli.

作者信息

Carbone M, Hasty D L, Yi K C, Rue J, Fera M T, La Torre F, Giannone M, Losi E

机构信息

Dipartimentodi Patologia e Microbiologia Sperimentale, Facolta di Medicina e Chirurgia, Universita di Messina, Messina, Italy.

出版信息

Ann N Y Acad Sci. 2002 Jun;963:332-5. doi: 10.1111/j.1749-6632.2002.tb04127.x.

DOI:10.1111/j.1749-6632.2002.tb04127.x

PMID:12095961

Abstract

The local cytokine response to uropathogenic phenotype Escherichia coli KBC211 infection exhibits characteristics of both TH1 and TH2 profiles. Interleukin (IL)-6, MIP-2, IL-12, IL-18, and tumor necrosis factor-alpha (TNF-alpha) are expressed, but IL-4, IL-5, and IL-10 are also present at low levels. This is clearly a complex response that should be explored more fully. The relative contributions of the bladder epithelium and other cells of the bladder wall should also be determined. Epithelial cytokine responses may be considerable, and because these cells are the first to encounter the pathogen, they will be of great importance in the immune response to pathogenic E. coli.

摘要

对尿路致病性表型大肠杆菌KBC211感染的局部细胞因子反应表现出TH1和TH2两种特征。白细胞介素（IL）-6、巨噬细胞炎症蛋白-2（MIP-2）、IL-12、IL-18和肿瘤坏死因子-α（TNF-α）均有表达，但IL-4、IL-5和IL-10也有低水平存在。这显然是一种复杂的反应，需要更全面地进行探究。膀胱上皮和膀胱壁其他细胞的相对作用也应予以确定。上皮细胞因子反应可能相当可观，而且由于这些细胞是最先接触病原体的，它们在对致病性大肠杆菌的免疫反应中将具有重要意义。