关于：阻断致癌性Ras信号通路用于癌症治疗 - Suppr

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Re: Blocking oncogenic Ras signaling for cancer therapy.

作者信息

Canevari Silvana, Biocca Silvia, Figini Mariangela

出版信息

J Natl Cancer Inst. 2002 Jul 3;94(13):1031-2; author reply 1032. doi: 10.1093/jnci/94.13.1031.

DOI:10.1093/jnci/94.13.1031

PMID:12096090

Abstract

摘要

相似文献

Re: Blocking oncogenic Ras signaling for cancer therapy.关于：阻断致癌性Ras信号通路用于癌症治疗

J Natl Cancer Inst. 2002 Jul 3;94(13):1031-2; author reply 1032. doi: 10.1093/jnci/94.13.1031.

Blocking oncogenic Ras signaling for cancer therapy.阻断致癌性Ras信号通路用于癌症治疗。

J Natl Cancer Inst. 2001 Jul 18;93(14):1062-74. doi: 10.1093/jnci/93.14.1062.

Farnesyltransferase inhibitors and cancer treatment: targeting simply Ras?法尼基转移酶抑制剂与癌症治疗：仅仅靶向Ras吗？

Biochim Biophys Acta. 1997 Aug 8;1333(1):F51-71. doi: 10.1016/s0304-419x(97)00011-5.

Inhibitors of the ras oncogene as therapeutic targets.作为治疗靶点的ras癌基因抑制剂。

Hematol Oncol Clin North Am. 2002 Oct;16(5):1065-88. doi: 10.1016/s0889-8588(02)00050-3.

Inhibition of Ras prenylation: a signaling target for novel anti-cancer drug design.抑制Ras异戊二烯化：新型抗癌药物设计的信号靶点。

Anticancer Drug Des. 1997 Jun;12(4):229-38.

Ras farnesyltransferase inhibition: a novel and safe approach for cancer chemotherapy.Ras法尼基转移酶抑制：一种用于癌症化疗的新型安全方法。

Acta Pharmacol Sin. 2000 May;21(5):396-404.

Inhibition of Ras prenylation: a novel approach to cancer chemotherapy.抑制Ras蛋白异戊二烯化：癌症化疗的新方法。

Pharmacol Ther. 1997;74(1):103-14. doi: 10.1016/s0163-7258(97)00014-4.

The development of protein farnesyltransferase inhibitors as signaling-based anticancer agents.蛋白质法尼基转移酶抑制剂作为基于信号传导的抗癌药物的研发。

Prog Cell Cycle Res. 2003;5:211-7.

Farnesyl protein transferase inhibitors and other therapies targeting the Ras signal transduction pathway.

Invest New Drugs. 1999;17(3):241-58. doi: 10.1023/a:1006380320290.

Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines.抑制K-Ras的异戊二烯化，而非H-Ras或N-Ras的异戊二烯化，对CAAX肽模拟物具有高度抗性，并且在人肿瘤细胞系中需要法尼基转移酶和香叶基香叶基转移酶I抑制剂两者共同作用。

Oncogene. 1997 Sep;15(11):1283-8. doi: 10.1038/sj.onc.1201296.

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