Harbuz Michael S, Chover-Gonzalez Anjo, Gibert-Rahola Juan, Jessop David S
University Research Centre for Neuroendocrinology, University of Bristol, BRI, Marlborough Street, Bristol, BS2 8HW, United Kingdom.
Brain Behav Immun. 2002 Aug;16(4):439-49. doi: 10.1006/brbi.2001.0658.
Previous studies have revealed that a single exposure to an acute stress or acute immune stimulus can produce long-lasting changes in the activity and responsiveness of the hypothalamo-pituitary-adrenal (HPA) axis. The HPA axis is believed to be an important component in determining the susceptibility and severity of inflammation in autoimmune disease models such as adjuvant-induced arthritis (AA). In the present study we have tested the hypothesis that a single exposure to either footshock or lipopolysaccharide (LPS) 3 weeks prior to adjuvant injection can alter susceptibility to AA. Changes in HPA axis parameters were also determined. The results demonstrated that prior exposure to LPS conferred resistance to inflammation in AA, which was not related to a delay in onset of inflammation but rather an alteration in susceptibility. In contrast, prior exposure to the acute stress of footshock did not alter susceptibility. HPA axis parameters were increased in adjuvant-injected rats whether inflammation was present or not. These data suggest that prior exposure to acute immune stimuli, but not to acute footshock stress, may alter susceptibility to inflammation in the rat AA model. These changes in susceptibility do not appear to be solely mediated by increases in HPA axis activity, which were apparent in all AA groups irrespective of the presence of inflammation.
先前的研究表明，单次暴露于急性应激或急性免疫刺激可使下丘脑 - 垂体 - 肾上腺（HPA）轴的活性和反应性产生持久变化。HPA轴被认为是在自身免疫性疾病模型（如佐剂性关节炎（AA））中决定炎症易感性和严重程度的重要组成部分。在本研究中，我们测试了这样一个假设：在注射佐剂前3周单次暴露于足部电击或脂多糖（LPS）可改变对AA的易感性。还测定了HPA轴参数的变化。结果表明，预先暴露于LPS可使大鼠对AA中的炎症产生抗性，这与炎症发作延迟无关，而是与易感性改变有关。相比之下，预先暴露于足部电击的急性应激并未改变易感性。无论是否存在炎症，注射佐剂的大鼠的HPA轴参数均升高。这些数据表明，预先暴露于急性免疫刺激而非急性足部电击应激可能会改变大鼠AA模型中对炎症的易感性。这些易感性的变化似乎并非仅由HPA轴活性增加介导，在所有AA组中，无论是否存在炎症，HPA轴活性增加都是明显的。
