Haruyama N, Igarashi K, Saeki S, Otsuka-Isoya M, Shinoda H, Mitani H
Division of Orthodontics, Department of Life-Long Oral Health Science, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
J Dent Res. 2002 Jun;81(6):406-10. doi: 10.1177/154405910208100610.
Sex hormones, including estradiol, play important physiological roles in bone metabolism. The purpose of this study was to investigate whether there is estrous-cycle-dependent variation in orthodontic tooth movement, and, if so, to determine the mechanism. Ten-week-old female Wistar rats were used. They received repeated orthodontic force during specific phases in the estrous cycle. Tooth movement in animals that received force principally in estrus was about 33% greater than that in animals that received such force principally in pro-estrus (p < 0.05). Serum estradiol levels also varied according to the estrous cycle, with a peak during pro-estrus and a nadir during estrus, and were inversely related to tooth movement. Furthermore, there were negative correlations between estradiol and both serum TRAP activity and pyridinoline (r = -0.42, p < 0.05; r = -0.59, p < 0.001). These results suggest that cyclic changes in the estradiol level may be associated with the estrous-cycle-dependent variation in tooth movement through its effects on bone resorption.
包括雌二醇在内的性激素在骨代谢中发挥着重要的生理作用。本研究的目的是调查正畸牙齿移动是否存在发情周期依赖性变化，如果存在，则确定其机制。使用10周龄的雌性Wistar大鼠。它们在发情周期的特定阶段接受反复的正畸力。主要在发情期接受力的动物的牙齿移动比主要在发情前期接受力的动物大33%左右（p<0.05）。血清雌二醇水平也随发情周期而变化，在发情前期达到峰值，在发情期达到最低点，并且与牙齿移动呈负相关。此外，雌二醇与血清TRAP活性和吡啶啉均呈负相关（r=-0.42，p<0.05；r=-0.59，p<0.001）。这些结果表明，雌二醇水平的周期性变化可能通过其对骨吸收的影响与发情周期依赖性牙齿移动变化相关。
