Webster Diane E, Cooney Michelle L, Huang Zhongjun, Drew Damien R, Ramshaw Ian A, Dry Ian B, Strugnell Richard A, Martin Jenny L, Wesselingh Steve L
Department of Medicine, Monash University Medical School, Alfred Hospital, Prahran, Victoria 3181, Australia.
J Virol. 2002 Aug;76(15):7910-2. doi: 10.1128/jvi.76.15.7910-7912.2002.
Despite eradication attempts, measles remains a global health concern. Here we report results that demonstrate that a single-dose DNA immunization followed by multiple boosters, delivered orally as a plant-derived vaccine, can induce significantly greater quantities of measles virus-neutralizing antibodies than immunization with either DNA or plant-derived vaccines alone. This represents the first demonstration of an enhanced immune response to a prime-boost vaccination strategy combining a DNA vaccine with edible plant technology.
尽管进行了根除努力，麻疹仍然是全球卫生关注的问题。在此，我们报告的结果表明，作为植物源疫苗口服给药，单剂量DNA免疫后多次加强免疫，比单独使用DNA疫苗或植物源疫苗免疫能诱导产生数量显著更多的麻疹病毒中和抗体。这是首次证明将DNA疫苗与可食用植物技术相结合的初免-加强疫苗接种策略可增强免疫反应。
