Selivanova K F, Romaskevych A I
Ukr Biokhim Zh. 1975 Mar-Apr;47(2):194-8.
Trypsin hydrolyzates of blood serum albumin of healthy people and patients with diffuse thyrotoxicosis and hypothyreosis were studied by the cellulose thin-layer electrochromatography. All the patients were found to have changes in the peptide composition of albumin trypsin hydrolyzate which resulted in disappearance of some peptides as well as in the appearance of new ones. Simultaneously conducted measurements of dispersion of optical rotation detected some changes in spectropolarimetric characteristics which provide the evidence for disperalization of its molecule. The found changes in albumin are determined by the disorder of normal protein biosynthesis and possible metabolic damage of protein.
采用纤维素薄层层析法研究了健康人、弥漫性甲状腺毒症患者及甲状腺功能减退症患者血清白蛋白的胰蛋白酶水解产物。发现所有患者白蛋白胰蛋白酶水解产物的肽组成均有变化，导致一些肽消失，同时出现新的肽。同时进行的旋光色散测量检测到旋光光谱特征的一些变化，这为其分子的分散化提供了证据。白蛋白中发现的这些变化是由正常蛋白质生物合成紊乱和蛋白质可能的代谢损伤所决定的。
