Shirokova T Y, Trapeznikov A A, Kovarova L V
Ukr Biokhim Zh. 1975 Jul-Aug;47(4):428-33.
When the monolayers of trypsin are compressed on the surface of the medicinal substances solution they remain mixed even when high pressure is applied. The experiments on reversibility also indicate that certain medicinal substances remain in the monolayers. An increase in the surface pressure causes partial (dimedrol, barbamyl) or complete (analgin, amidopyrin) displacement of medicinal substances out of the trypsin monolayer. This proves that there is no strong interaction between them. Unlike proteins, the monolayer of acetyl alcohol is less penetrable and indicates the absence of interaction with dimedrol where the mature of the monolayer is of great importance.
当胰蛋白酶单分子层在药物溶液表面被压缩时,即使施加高压它们仍保持混合状态。关于可逆性的实验也表明某些药物会留在单分子层中。表面压力的增加会导致药物从胰蛋白酶单分子层中部分(苯海拉明、巴比妥)或完全(安乃近、氨基比林)被置换出来。这证明它们之间不存在强相互作用。与蛋白质不同,乙醇单分子层的渗透性较小,表明在单分子层性质非常重要的情况下,它与苯海拉明不存在相互作用。