Zupan Igor, Kozelj Mirta, Butinar Janos, Rakovec Peter
Department of Cardiology, University Medical Centre Ljubljana, Zaloska 7, 1000 Ljubljana, Slovenia.
Cell Mol Biol Lett. 2002;7(2):383-4.
In animal and human studies, it has been shown that atrial fibrillation shortens the atrial refractory period and impairs its rate adaptation. The objective of this study was to evaluate the effects of high-rate pacing on sinus node function and intra-atrial conduction. Eight dogs were subjected to rapid atrial pacing (AP) at 400 bpm for 16 days. Sinus node recovery time (SNRT) and P-wave duration were measured at baseline, immediately after AP and four weeks after the termination of AP. SNRT immediately after AP was significantly prolonged at all pacing rates compared to the baseline values. P-wave duration was significantly longer after AP relative to the baseline values. All the variables were completely reversible four weeks after the termination of pacing. Rapid AP induces sinus node dysfunction and prolongs the intra-atrial conduction time. It is possible that the electrical remodelling extends to the sinus node as well.
在动物和人体研究中，已表明心房颤动会缩短心房不应期并损害其频率适应性。本研究的目的是评估高频率起搏对窦房结功能和心房内传导的影响。八只犬接受了400次/分钟的快速心房起搏（AP），持续16天。在基线、AP结束后即刻以及AP终止后四周测量窦房结恢复时间（SNRT）和P波时限。与基线值相比，所有起搏频率下AP结束后即刻的SNRT均显著延长。AP后P波时限相对于基线值显著延长。起搏终止四周后所有变量均完全可逆。快速AP诱发窦房结功能障碍并延长心房内传导时间。电重构也有可能延伸至窦房结。
