Oxiranyl anion-mediated synthesis of highly enantiomerically enriched styrene oxide derivatives.

作者信息

Capriati Vito, Florio Saverio, Luisi Renzo, Salomone Antonio

机构信息

C.N.R., Istituto di Chimica dei Composti OrganoMetallici-ICCOM, Sezione di Bari, Dipartimento Farmaco-Chimico, Università di Bari, Via E.Orabona 4, I-70126 Bari, Italy.

出版信息

Org Lett. 2002 Jul 11;4(14):2445-8. doi: 10.1021/ol026212d.

DOI:10.1021/ol026212d

PMID:12098268

Abstract

[reaction: see text] The stereospecific alpha-lithiation of optically active styrene oxides and the trapping reaction of the corresponding highly reactive intermediates with electrophiles to produce optically active styrene oxide derivatives are described. This methodology has been applied to the synthesis of an optically active oral antifungal agent of industrial interest.

摘要