手性二氧杂环丙烷通过类平面过渡态对1,1-二取代末端烯烃进行不对称环氧化反应。
Asymmetric epoxidation of 1,1-disubstituted terminal olefins by chiral dioxirane via a planar-like transition state.
作者信息
Wang Bin, Wong O Andrea, Zhao Mei-Xin, Shi Yian
机构信息
Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA.
出版信息
J Org Chem. 2008 Dec 19;73(24):9539-43. doi: 10.1021/jo801576k.
Abstract
Various 1,1-disubstituted terminal olefins have been investigated for asymmetric epoxidation using chiral ketone catalysts. Up to 88% ee has been achieved with a lactam ketone, and a planar transition state is likely to be a major reaction pathway.
摘要
已使用手性酮催化剂对各种1,1-二取代末端烯烃进行不对称环氧化研究。使用内酰胺酮时，对映体过量值（ee）高达88%，平面过渡态可能是主要反应途径。
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