Taber Douglass F, Jiang Qin, Chen Bei, Zhang Wei, Campbell Carlton L
Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA.
J Org Chem. 2002 Jul 12;67(14):4821-7. doi: 10.1021/jo020103v.
The first total synthesis of (-)-calicoferol B (III) is described. The cyclozirconation product I, prepared in enantiomerically pure form, was converted into the CD ring chiron II. This was coupled with the aromatic A-ring, and then the side chain was constructed with control of relative and absolute configuration to complete the total synthesis of III. The first total synthesis of (-)-calicoferol B (1) is described. The cyclozirconation product 8, prepared in enantiomerically pure form, was converted into the CD ring chiron 6. This was coupled with the aromatic A-ring, and then the side chain was constructed with control of relative and absolute configuration to complete the total synthesis of 1.
描述了（-）-加利福罗醇B（III）的首次全合成。以对映体纯形式制备的环锆化产物I被转化为CD环手性中间体II。将其与芳香族A环偶联，然后构建侧链并控制相对和绝对构型以完成III的全合成。描述了（-）-加利福罗醇B（1）的首次全合成。以对映体纯形式制备的环锆化产物8被转化为CD环手性中间体6。将其与芳香族A环偶联，然后构建侧链并控制相对和绝对构型以完成1的全合成。
