Tallarida Ronald J
Department of Pharmacology and Center on Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA 19140, USA.
Pain. 2002 Jul;98(1-2):163-8. doi: 10.1016/s0304-3959(02)00041-6.
Two drugs used in combination may produce enhanced or reduced effects. The degree of enhancement or reduction is measured from the interaction index (gamma), a quantity that indicates the changed potency of the combination. The index is therefore a quantitative marker for the drug combination and effect metric used. Methodology for measuring the interaction index utilizes the combination and individual drug dose-effect data suitably modeled by regression techniques that most often produce linear plots of effect on log dose from which isobolar analysis is employed. The isobologram provides a simple and convenient graphical assessment of the interaction index but an independent statistical analysis is needed to assess its precision. In some cases, the relative potency of the constituent drugs is the same at all effect levels. When this is so, it is shown that the interaction index can be measured by either an isobolar or an alternate method that is illustrated here. These calculations demonstrate that these different methods of analysis yield the same value of gamma, and do so with comparable precision.
两种联合使用的药物可能会产生增强或减弱的效果。增强或减弱的程度通过相互作用指数（γ）来衡量，该指数表示联合用药效力的变化。因此，该指数是所用药物组合和效应指标的定量标志物。测量相互作用指数的方法利用联合用药和单一药物的剂量-效应数据，这些数据通过回归技术进行适当建模，回归技术通常会生成效应与对数剂量的线性图，据此采用等效线分析。等效线图提供了一种简单方便的相互作用指数图形评估方法，但需要进行独立的统计分析来评估其精确性。在某些情况下，组成药物的相对效力在所有效应水平上都是相同的。当情况如此时，结果表明相互作用指数可以通过等效线法或此处说明的另一种方法来测量。这些计算表明，这些不同的分析方法得出的γ值相同，并且具有相当的精确性。
