Kenny H A, Bernard D J, Horton T H, Woodruff T K
Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA.
J Endocrinol. 2002 Jul;174(1):85-94. doi: 10.1677/joe.0.1740085.
Inhibin production differs in ovaries of Siberian hamsters (Phodopus sungorus) exposed to long days (LD) or short days (SD). We believe that seasonal differences in serum follicle-stimulating hormone contribute to this difference. However, given the profound photoperiodic differences in follicle maturation, serum gonadotropins alone may not account for all of the observed differences in inhibin processing. To test this hypothesis, we challenged LD and SD female hamsters with exogenous gonadotropins. While both groups responded with increased inhibin expression, the effects were muted in ovaries of SD females and there was no evidence of ovulation in these animals. These data indicate that the ovaries of SD females are not immediately equipped to respond to gonadotropin stimulation. More generally, these data suggest that photoperiodic history affects ovarian inhibin production and secretion in response to gonadotropins.
暴露于长日照（LD）或短日照（SD）条件下的西伯利亚仓鼠（Phodopus sungorus）卵巢中抑制素的产生存在差异。我们认为，血清促卵泡激素的季节性差异导致了这种差异。然而，鉴于卵泡成熟过程中存在显著的光周期差异，仅血清促性腺激素可能无法解释抑制素加工过程中观察到的所有差异。为了验证这一假设，我们用外源性促性腺激素刺激长日照和短日照条件下的雌性仓鼠。虽然两组的抑制素表达均增加，但短日照雌性仓鼠卵巢中的效应较弱，且这些动物没有排卵迹象。这些数据表明，短日照雌性仓鼠的卵巢不能立即对促性腺激素刺激做出反应。更普遍地说，这些数据表明光周期经历会影响卵巢对促性腺激素刺激产生和分泌抑制素的过程。
