Blanck George
Department of Biochemistry and Molecular Biology, Moffitt Cancer Center, University of South Florida College of Medicine, MDC Box 7, 12901 Bruce B. Downs Blvd. MDC7, Tampa, FL 33612, USA.
Arch Immunol Ther Exp (Warsz). 2002;50(3):151-8.
Many features of the interferon gamma (IFN-gamma) signaling pathway would suggest that it is anti-tumorigenic. The IFN-gamma signaling pathway leads to apoptosis and to the expression of immune function proteins that could cooperate with T cells in the destruction of tumor. Various lines of experimental approach have, in general, supported the hypothesis that the IFN-gamma signaling pathway is anti-tumorigenic. However, data also indicate that the idea that the IFN-gamma signaling pathway is exclusively anti-tumorigenic is too simplistic. Also, to date, very little of the knowledge regarding the anti-tumor effects of the IFN-gamma pathway has been useful in the prognosis or therapy of cancer. This review summarizes the current state of knowledge regarding the IFN-gamma signaling pathway in tumorigenesis, with an emphasis on MHC class II induction in tumor cells and the induction of apoptosis in tumor cells. The review also indicates some future areas of investigation that offer hope for applying this knowledge in reducing cancer mortality.
干扰素γ（IFN-γ）信号通路的许多特征表明它具有抗肿瘤作用。IFN-γ信号通路可导致细胞凋亡，并促使免疫功能蛋白表达，这些蛋白可与T细胞协同作用以破坏肿瘤。总体而言，各种实验方法均支持IFN-γ信号通路具有抗肿瘤作用这一假说。然而，数据也表明，认为IFN-γ信号通路完全具有抗肿瘤作用的观点过于简单。此外，迄今为止，关于IFN-γ通路抗肿瘤作用的知识在癌症的预后或治疗中几乎没有什么用处。本综述总结了目前关于IFN-γ信号通路在肿瘤发生中的知识现状，重点关注肿瘤细胞中MHC II类分子的诱导以及肿瘤细胞凋亡的诱导。该综述还指出了一些未来的研究领域，这些领域为将这些知识应用于降低癌症死亡率带来了希望。
