人类ASCL2基因逃避基因组印记及其表达模式。
The human ASCL2 gene escaping genomic imprinting and its expression pattern.
作者信息
Miyamoto Toshinobu, Hasuike Shiga, Jinno Yoshihiro, Soejima Hidenobu, Yun Kankatsu, Miura Kiyonori, Ishikawa Mutsuo, Niikawa Norio
机构信息
Department of Human Genetics, School of Medicine, Nagasaki University, Japan.
出版信息
J Assist Reprod Genet. 2002 May;19(5):240-4. doi: 10.1023/a:1015362903486.
Abstract
The mouse achaete-scute homolog-2 gene (Ascl2 or Mash2) encodes a transcription factor playing a role in the development of the trophoblast. The Ascl2 is an imprinted gene with maternal expression and assigned to an imprinting gene cluster region (ICR) at a distal region of mouse chromosome 7. We previously isolated a phage clone carrying the human homolog, ASCL2, and mapped it to human chromosome 11p15.5, a human ICR. In the present study, we demonstrate the expression patterns of the human ASCL2 in the fetus at a stage between first and second trimesters and in the placental tissues. In addition, it has been shown that the human ASCL2 gene escapes genomic imprinting.
摘要
小鼠无刚毛-毛状同系物2基因（Ascl2或Mash2）编码一种在滋养层发育中起作用的转录因子。Ascl2是一个母源表达的印记基因，定位于小鼠7号染色体远端区域的一个印记基因簇区域（ICR）。我们之前分离出一个携带人类同源物ASCL2的噬菌体克隆，并将其定位于人类11号染色体p15.5区域，这是一个人类ICR。在本研究中，我们展示了人类ASCL2在孕早期和孕中期之间阶段的胎儿以及胎盘组织中的表达模式。此外，已表明人类ASCL2基因逃避了基因组印记。
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