用免疫调节剂咪喹莫特成功治疗肛门生殖器鲍恩病，并通过DNA图像细胞术监测治疗情况。

Successful treatment of anogenital Bowen's disease with the immunomodulator imiquimod, and monitoring of therapy by DNA image cytometry.

作者信息

Gutzmer R, Kaspari M, Vogelbruch M, Kiehl P, Kapp A, Werfel T, Brodersen J-P

机构信息

Department of Dermatology and Allergology, Hannover Medical University, Ricklinger Str. 5, Germany.

出版信息

Br J Dermatol. 2002 Jul;147(1):160-5. doi: 10.1046/j.1365-2133.2002.04729.x.

DOI:10.1046/j.1365-2133.2002.04729.x

PMID:12100202

Abstract

Imiquimod (Aldara, 3M) is an immune response modifier used for the treatment of anogenital warts. We report a 55-year-old non-immunocompromised woman with extensive, human papillomavirus (HPV) 16-positive anogenital Bowen's disease. After 5 months of local treatment with imiquimod, the lesions completely regressed clinically and histologically, and HPV 16 DNA was no longer detectable. Moreover, DNA image cytometry revealed DNA aneuploidy (an indicator of prospective malignancy) in pretreatment samples but not in post-treatment samples. Therefore, imiquimod might be a treatment option for Bowen's disease, particularly in patients where other treatment modalities such as surgery are contraindicated.

摘要

咪喹莫特（艾达乐，3M公司）是一种用于治疗肛门生殖器疣的免疫反应调节剂。我们报告了一名55岁无免疫功能低下的女性，患有广泛的、人乳头瘤病毒（HPV）16阳性的肛门生殖器鲍温病。在用咪喹莫特进行局部治疗5个月后，病变在临床和组织学上完全消退，且不再能检测到HPV 16 DNA。此外，DNA图像细胞术显示治疗前样本中有DNA非整倍体（一种潜在恶性肿瘤的指标），但治疗后样本中没有。因此，咪喹莫特可能是鲍温病的一种治疗选择，特别是对于那些禁忌手术等其他治疗方式的患者。