乳腺癌中的细胞周期蛋白：过犹不及。
Cyclins in breast cancer: too much of a good thing.
作者信息
Enders Greg H
机构信息
Penn/GI Division, Suite 600/CRB, 415 Curie Boulevard, Philadelphia, PA 19104-6144, USA.
出版信息
Breast Cancer Res. 2002;4(4):145-7. doi: 10.1186/bcr439. Epub 2002 Jun 7.
Abstract
Cyclin E, a key mediator of entry into the cell division cycle, is expressed abundantly in many breast cancers. However, amplification of the cognate gene is observed rarely, leaving the responsible mechanism(s) and its importance in tumorigenesis in doubt. In a recent report, Steve Reed's lab demonstrates that hCdc4/Fbw7 targets cyclin E for ubiquitin-mediated proteolysis and is mutant in a breast cancer cell line with high cyclin E levels. Independent work demonstrates that a Drosophila hCdc4 homologue constrains cyclin E expression in vivo. These results suggest that lesions in protein degradation pathways may contribute to cyclin E deregulation in breast cancer.
摘要
细胞周期蛋白E是进入细胞分裂周期的关键调节因子，在许多乳腺癌中大量表达。然而，同源基因的扩增很少见，其相关机制及其在肿瘤发生中的重要性仍存在疑问。在最近的一份报告中，史蒂夫·里德的实验室证明，hCdc4/Fbw7靶向细胞周期蛋白E进行泛素介导的蛋白水解，并且在一个细胞周期蛋白E水平高的乳腺癌细胞系中发生了突变。独立研究表明，果蝇hCdc4同源物在体内限制细胞周期蛋白E的表达。这些结果表明，蛋白质降解途径中的损伤可能导致乳腺癌中细胞周期蛋白E的失调。
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