Brunet Jean-François, Pattyn Alexandre
CNRS UMR 8542, Ecole Normale Supérieure, 46 rue d'Ulm, 75005 Paris, France.
Curr Opin Genet Dev. 2002 Aug;12(4):435-40. doi: 10.1016/s0959-437x(02)00322-2.
In the developing brain, many transcription factors are expressed in complex patterns and dynamics, and drive the differentiation of many classes of neurons. How does the spatio-temporal landscape of transcription factor expression map onto the bewildering variety of neuronal types, and, for each of them, the variety of developmental stages they go through? In other words, what is the logic in the transcriptional control of neuronal differentiation? Here, we review what recent work on the two neuronal-type-specific transcription factors Phox2a and Phox2b has contributed to our understanding of this broad question.
在发育中的大脑中，许多转录因子以复杂的模式和动态表达，并驱动多种类型神经元的分化。转录因子表达的时空格局是如何映射到令人眼花缭乱的各种神经元类型上的，以及对于每一种神经元类型，它们所经历的各种发育阶段又是如何映射的？换句话说，神经元分化的转录控制中的逻辑是什么？在这里，我们回顾了关于两种神经元类型特异性转录因子Phox2a和Phox2b的最新研究工作对我们理解这个广泛问题所做出的贡献。
