细胞色素CYP26B1（P450RAI-2）在人头部组织中的发育表达。
Developmental expression of cytochrome CYP26B1 (P450RAI-2) in human cephalic tissues.
作者信息
Trofimova-Griffin Marina E, Juchau Mont R
机构信息
Department of Pharmacology, School of Medicine, Box 357280, University of Washington, Seattle, WA 98195-7280, USA.
出版信息
Brain Res Dev Brain Res. 2002 Jun 30;136(2):175-8. doi: 10.1016/s0165-3806(02)00305-x.
Expression levels of cytochrome CYP26B1, which is involved in the specific all-trans-RA inactivation, were evaluated in human cephalic tissues at gestational days 57-110 and exhibited values approximately 10-fold higher than later gestational days 112-224 and adult tissues. CYP26B1 mRNA levels in the adult cerebellum were approximately 2-fold higher than in the adult whole brain tissue. Considered together, these data suggest a unique role for CYP26B1 during human brain development.
参与特定全反式视黄酸失活的细胞色素CYP26B1在妊娠第57 - 110天的人类头部组织中的表达水平进行了评估，其值比妊娠后期第112 - 224天及成人组织高出约10倍。成人大脑中CYP26B1 mRNA水平比成人全脑组织高出约2倍。综合来看，这些数据表明CYP26B1在人类大脑发育过程中具有独特作用。
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