Balaba T Y, Panova M I, Furtseva L N, Bukhtoyarova F G
Vopr Med Khim. 1975 May-Jun;21(3):290-5.
Distinct impairments in collagen metabolism were observed in infectious (rheumatoid) polyarthritis. The impairements were manifested as increased excretion of hydroxyproline with urine and increased content of protein bound hydroxyproline in blood plasma and synovial fluid; the impairements increased with an increased in severity and abundance of pathological process in connective tissue. After successful treatment of patients (surgical operation, combined with complex antirheumatic treatment) content of the collagen metabolites was decreased in biological fluids; this decrease was not observed if the inflammatory process in the connective tissue was present.
在感染性（类风湿性）多关节炎中观察到胶原代谢存在明显损害。这些损害表现为尿中羟脯氨酸排泄增加以及血浆和滑液中蛋白结合羟脯氨酸含量增加；随着结缔组织中病理过程的严重程度和丰富度增加，这些损害也会加重。在患者成功接受治疗（手术，联合复杂的抗风湿治疗）后，生物体液中胶原代谢产物的含量降低；如果结缔组织中存在炎症过程，则未观察到这种降低。
