Arya M
Acta Eur Fertil. 1979 Sep;10(3):131-4.
Short courses of cyproterone acetate, a compound with progestational and antiandrogenic activities were administered to normally cycling female monkeys to investigate into the effects of cyproterone acetate on the reproductive tract. In little earlier follicular stage 20 mg of the drug daily for 30 days increased the cholesterol contents in the gonads. Serum cholesterol contents were slightly increased. When the reproductive tract was examined histologically, the gonads showed reduction in size, along with widespread degeneration of the young follicles as well as other growing follicles. Uterus showed progestational endometrial proliferation and sloughing of the vaginal productive tract.
给正常月经周期的雌性猴子注射具有孕激素和抗雄激素活性的醋酸环丙孕酮短疗程药物，以研究醋酸环丙孕酮对生殖道的影响。在卵泡早期稍早阶段，每天注射20毫克该药物，持续30天，可使性腺中的胆固醇含量增加。血清胆固醇含量略有增加。对生殖道进行组织学检查时，性腺体积减小，同时年轻卵泡以及其他生长卵泡普遍发生退化。子宫出现孕激素引起的子宫内膜增生以及阴道生殖道的脱落。
