1999 - 2000年期间加替沙星与其他抗生素对美国4009株肺炎链球菌临床分离株的比较活性
Comparative activity of gatifloxacin and other antibiotics against 4009 clinical isolates of Streptococcus pneumoniae in the United States during 1999-2000.
作者信息
White Roger L, Enzweiler Kevin A, Friedrich Lawrence V, Wagner David, Hoban Daryl, Bosso John A
机构信息
Anti-infective Research Laboratory, Medical University of South Carolina, Charleston, USA.
出版信息
Diagn Microbiol Infect Dis. 2002 Jul;43(3):207-17. doi: 10.1016/s0732-8893(02)00391-7.
The susceptibility of 4009 recent clinical isolates of Streptococcus pneumoniae to gatifloxacin, levofloxacin, ciprofloxacin, penicillin, ceftriaxone and azithromycin was determined. Overall rates of susceptibility to these agents were 99.4, 98.7, 71.2, 55.2, 80.9, and 71.3%, respectively. Resistance to all tested agents was associated with penicillin resistance. Of penicillin nonsusceptible isolates, 36% were resistant. Resistance to the fluoroquinolones was unusual and gatifloxacin generally appeared to be four-fold more active than levofloxacin or ciprofloxacin. Multidrug resistant S. pneumoniae accounted for 6.2% of this sample. The lowest rate of susceptibility to non-fluoroquinolone antibiotics was observed in isolates from the South region of the United States, which appeared to be explained by both the proportion of and the inherently higher MICs of certain types of isolates.
测定了4009株近期临床分离的肺炎链球菌对加替沙星、左氧氟沙星、环丙沙星、青霉素、头孢曲松和阿奇霉素的敏感性。这些药物的总体敏感率分别为99.4%、98.7%、71.2%、55.2%、80.9%和71.3%。对所有测试药物的耐药性均与青霉素耐药性相关。在青霉素不敏感的分离株中，36%具有耐药性。对氟喹诺酮类药物的耐药情况不常见，加替沙星的活性通常似乎比左氧氟沙星或环丙沙星高四倍。多重耐药肺炎链球菌占该样本的6.2%。在美国南部地区分离株中观察到对非氟喹诺酮类抗生素的最低敏感率，这似乎可以通过某些类型分离株的比例及其固有较高的最低抑菌浓度来解释。
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