1型酒精依赖患者持续完全缓解状态下的血小板单胺氧化酶-B活性
Platelet monoamine oxidase-B activity in type 1 alcohol-dependent subjects in sustained full remission.
作者信息
Berggren Ulf, Eriksson Matts, Fahlke Claudia, Blennow Kaj, Sundkler Anders, Balldin Jan
机构信息
The Sahlgrenska Academy at Göteborg University, Institute of Clinical Neuroscience, Psychiatric Section, Sahlgrenska University Hospital/Mölndal, SE-431 80 Mölndal and Department of Psychology, Göteborg University, Göteborg, Sweden.
出版信息
Alcohol Alcohol. 2002 Jul-Aug;37(4):340-3. doi: 10.1093/alcalc/37.4.340.
AIMS
The present study investigated platelet monoamine oxidase-B (MAO-B) activity in male alcohol-dependent subjects in sustained full remission (minimum 1 year), to exclude possible transient changes in platelet MAO-B activity, which occur up to several months after the end of alcohol intake.
METHODS
MAO-B activity was examined in 16 alcohol-dependent subjects, characterized as type 1 alcoholics, with an abstinence period of 6 +/- 7 years (mean +/- SD) and in 12 healthy controls.
RESULTS
The long-term abstinent alcohol-dependent subjects did not differ from controls in platelet MAO-B activity.
CONCLUSIONS
Type 1 male alcohol-dependent subjects appear to have normal platelet MAO-B activity. The possibility, however, cannot be excluded that type 2 long-term abstinent alcoholics may have lower platelet MAO-B activity.
目的
本研究调查了处于持续完全缓解状态（至少1年）的男性酒精依赖者的血小板单胺氧化酶-B（MAO-B）活性，以排除酒精摄入结束后长达数月出现的血小板MAO-B活性可能的短暂变化。
方法
检测了16名酒精依赖者（特征为1型酗酒者）的MAO-B活性，其戒酒期为6±7年（均值±标准差），并检测了12名健康对照者的MAO-B活性。
结果
长期戒酒的酒精依赖者与对照者在血小板MAO-B活性方面无差异。
结论
1型男性酒精依赖者似乎具有正常的血小板MAO-B活性。然而，不能排除2型长期戒酒的酗酒者血小板MAO-B活性可能较低的可能性。
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