有家族史阳性和家族史阴性的 1 型酒精依赖受试者的血小板单胺氧化酶 B
Platelet monoamine oxidase B in family history positive and family history negative type 1 alcohol-dependent subjects.
作者信息
Berggren Ulf, Eriksson Matts, Fahlke Claudia, Blennow Kaj, Balldin Jan
机构信息
The Sahlgrenska Academy at Göteborg University, Institute of Clinical Neuroscience, Sahlgrenska University Hospital/Mölndal, SE-431 80 Mölndal, Sweden.
出版信息
Alcohol Alcohol. 2002 Nov-Dec;37(6):577-80. doi: 10.1093/alcalc/37.6.577.
AIMS AND METHODS
In the present study platelet monoamine oxidase B (MAO-B) activity was investigated in 76 male type 1 alcohol-dependent subjects with and without a family history of alcoholism.
RESULTS
Platelet MAO-B activity did not differ between family history positive (FHP) and family history negative alcohol-dependent subjects. The smoking status of the subjects was registered and there was still no difference between the groups when possible effects of smoking were taken into account. It should, however, be noted that platelet MAO-B activity was lower in alcohol-dependent subjects with three or four alcohol-dependent first-degree relatives.
CONCLUSIONS
Although this latter finding should be interpreted with caution due to the small number of subjects, it cannot be excluded that FHP alcohol-dependent subjects with a large number of alcohol-dependent first-degree relatives may have lower platelet MAO-B activity.
目的与方法
在本研究中，对76名患有1型酒精依赖症的男性进行了血小板单胺氧化酶B（MAO-B）活性检测，这些男性有的有酗酒家族史，有的没有。
结果
有酗酒家族史（FHP）的酒精依赖者与无酗酒家族史的酒精依赖者之间，血小板MAO-B活性没有差异。记录了受试者的吸烟状况，考虑到吸烟可能产生的影响后，两组之间仍无差异。然而，应当注意的是，有三名或四名患有酒精依赖症的一级亲属的酒精依赖者，其血小板MAO-B活性较低。
结论
尽管由于受试者数量较少，后一项发现应谨慎解读，但不能排除有大量患有酒精依赖症的一级亲属的FHP酒精依赖者，其血小板MAO-B活性可能较低。
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