NM23表达作为结直肠癌的预后因素
NM23 expression as prognostic factor in colorectal carcinoma.
作者信息
Forte A, D'Urso A, Gallinaro L S, Lo Storto G, Soda G, Bosco D, Bezzi M, Vietri F, Beltrami V
机构信息
Department of Surgical Sciences and Applied Medical Technologies, Fourth Surgical Clinic, La Sapienza University, Rome.
出版信息
G Chir. 2002 Mar;23(3):61-3.
BACKGROUND
The current most important prognostic indicator in colorectal carcinoma is tumor stage at the moment of diagnosis. The role of NM23 gene as prognostic factor is controversial. The aim of this study was to investigate NM23 expression.
PATIENTS AND METHODS
The study population included 104 unselected patients who underwent surgery for colorectal carcinoma between 1992 and 1997. NM23 expression was quantified by estimating the percentage of tumor cells with unequivocal reactivity. The percentage was scored: 0 when no tumor cells showed immunoreactivity; 1 when less than 10% of cells showed immunoreactivity; 2 when 11-50% of cells were positive; 3 when more than 51% of cells were positive.
RESULTS
Four cases belonged to group 0.21 to group 1.55 to group 2 and 24 to group 3.
CONCLUSION
NM23 cannot be considered an independent prognostic variable.
背景
目前结直肠癌最重要的预后指标是诊断时的肿瘤分期。NM23基因作为预后因素的作用存在争议。本研究的目的是调查NM23的表达情况。
患者与方法
研究对象包括1992年至1997年间接受结直肠癌手术的104例未经挑选的患者。通过估计具有明确反应性的肿瘤细胞百分比来量化NM23的表达。该百分比评分如下：无肿瘤细胞显示免疫反应性时为0；少于10%的细胞显示免疫反应性时为1；11%-50%的细胞为阳性时为2；超过51%的细胞为阳性时为3。
结果
4例属于0组，21例属于1组，55例属于2组，24例属于3组。
结论
NM23不能被视为一个独立的预后变量。
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