细胞凋亡中的不稳定因素：播下IAP破坏的种子。
Destabilizing influences in apoptosis: sowing the seeds of IAP destruction.
作者信息
Martin Seamus J
机构信息
Molecular Cell Biology Laboratory, Department of Genetics, Trinity College, Dublin 2, Ireland.
出版信息
Cell. 2002 Jun 28;109(7):793-6. doi: 10.1016/s0092-8674(02)00802-4.
Abstract
Inhibitor of apoptosis proteins (IAPs) can block apoptosis through interactions with members of the caspase family of cysteine proteases. Recent developments suggest that ubiquitin-proteasome mediated destruction of the Drosophila IAP, DIAP1, is a key event during the initiation of programmed cell death in the fly.
摘要
凋亡抑制蛋白（IAPs）可通过与半胱氨酸蛋白酶的半胱天冬酶家族成员相互作用来阻断细胞凋亡。最近的研究进展表明，泛素-蛋白酶体介导的果蝇IAP（DIAP1）的降解是果蝇程序性细胞死亡起始过程中的关键事件。
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