Uyeda Kosaku, Yamashita Hiromi, Kawaguchi Takumi
Department of Biochemistry, Veterans Affairs Medical Center and The University of Texas Southwestern Medical Center at Dallas, 75216, USA.
Biochem Pharmacol. 2002 Jun 15;63(12):2075-80. doi: 10.1016/s0006-2952(02)01012-2.
Feeding a high carbohydrate diet induces transcription of more than 15 genes involved in the metabolic conversion of glucose to fat. A new transcription factor binding to a glucose response element of the pyruvate kinase and lipogenesis enzyme genes was discovered recently. This factor, termed carbohydrate responsive element-binding protein (ChREBP), is activated in response to high glucose and up-regulates these genes. Cyclic AMP and a high fat diet inhibit ChREBP and slow down glucose utilization. ChREBP is able to control transcription of lipogenic enzyme genes in response to nutritional and hormonal inputs, and may play an important role in disease states such as diabetes, obesity, and hypertension.
喂养高碳水化合物饮食会诱导超过15个参与葡萄糖代谢转化为脂肪的基因转录。最近发现了一种新的转录因子，它与丙酮酸激酶和脂肪生成酶基因的葡萄糖反应元件结合。这个因子被称为碳水化合物反应元件结合蛋白（ChREBP），它在高葡萄糖刺激下被激活，并上调这些基因。环磷酸腺苷（cAMP）和高脂肪饮食会抑制ChREBP并减缓葡萄糖利用。ChREBP能够根据营养和激素输入来控制脂肪生成酶基因的转录，并且可能在糖尿病、肥胖症和高血压等疾病状态中发挥重要作用。
