Ward-Robinson J, Wilton L A K, Muir J L, Honey R C, Vann S D, Aggleton J P
School of Psychology, Cardiff University, UK.
Behav Brain Res. 2002 Jul 18;133(2):125-33. doi: 10.1016/s0166-4328(01)00465-x.
Rats with neurotoxic lesions centered in the anterior thalamic nuclei were trained in two versions of a nonspatial, sensory preconditioning procedure. In both versions, two stimulus compounds (AX and BY) were first presented and then X, but not Y, was paired with an aversive unconditioned stimulus. This procedure resulted in greater conditioned responding to A than B. Anterior thalamic lesions had no apparent effect on these two examples of sensory preconditioning, nor did they affect fear conditioning or conditioned taste aversion. In contrast, the same lesions led to a severe deficit on a test of spatial memory. These results help to refine our understanding of the contribution of the anterior thalamic nuclei to spatial memory.
以丘脑前核为中心发生神经毒性损伤的大鼠，接受了两种非空间感觉预适应程序的训练。在这两种程序中，首先呈现两种刺激复合物（AX和BY），然后将X与厌恶无条件刺激配对，而Y不与厌恶无条件刺激配对。这一程序导致对A的条件反应比对B的条件反应更强。丘脑前核损伤对这两个感觉预适应例子没有明显影响，对恐惧条件反射或条件性味觉厌恶也没有影响。相比之下，相同的损伤导致空间记忆测试出现严重缺陷。这些结果有助于完善我们对丘脑前核对空间记忆贡献的理解。
