Stavnezer Amy Jo, Hyde Lynn A, Bimonte Heather A, Armstrong Cary M, Denenberg Victor H
Biobehavioral Sciences Graduate Degree Program, U-154, University of Connecticut, 3107 Horsebarn Hill Road, Storrs 06269-4154, USA.
Behav Brain Res. 2002 Jul 18;133(2):261-70. doi: 10.1016/s0166-4328(02)00021-9.
We recently developed a new nonspatial version of the Morris water maze that requires the use of four visually distinct intra-maze patterns to efficiently locate a hidden platform. The nonspatial version was designed to match the spatial version on complexity of cue usage, and differs only on spatiality of cues, thereby allowing more meaningful comparisons between the two versions. Following a previous experiment that demonstrated nonspatial learning with the BXSB inbred mouse strain, C57 inbred mice were tested in this study. They received spatial and nonspatial training in a counter-balanced order so that Test Order and information transfer could be assessed. Subjects that received spatial training first had superior performance in both the spatial and the nonspatial tasks when compared to mice that received nonspatial training first. The mice that received spatial training first used extra-maze cues as a spatial strategy. However, during nonspatial testing they did not use the intra-maze cues to locate the platform; instead, the mice used an egocentric strategy of circling through the platform annulus. Subjects that received spatial testing first were superior on the nonspatial task to those subjects that received nonspatial training first. Moreover, subjects that received nonspatial testing first were unable to learn the spatial version. Overall, C57 mice can learn both the spatial and nonspatial versions of the Morris maze presented here; however, the nonspatial version is more difficult and is solved using an egocentric strategy.
我们最近开发了一种新的非空间版本的莫里斯水迷宫，它需要使用四种视觉上不同的迷宫内部图案来有效地定位隐藏平台。非空间版本的设计旨在使线索使用的复杂性与空间版本相匹配，仅在线索的空间性上有所不同，从而能够在两个版本之间进行更有意义的比较。在先前一项证明BXSB近交系小鼠具有非空间学习能力的实验之后，本研究对C57近交系小鼠进行了测试。它们以平衡的顺序接受空间和非空间训练，以便可以评估测试顺序和信息传递。与首先接受非空间训练的小鼠相比，首先接受空间训练的受试者在空间任务和非空间任务中均表现更优。首先接受空间训练的小鼠将迷宫外部线索用作空间策略。然而，在非空间测试期间，它们并未使用迷宫内部线索来定位平台；相反，小鼠采用了一种以自我为中心的策略，即在平台环周围绕圈。首先接受空间测试的受试者在非空间任务上比首先接受非空间训练的受试者表现更优。此外，首先接受非空间测试的受试者无法学会空间版本。总体而言，C57小鼠可以学会此处呈现的莫里斯迷宫的空间和非空间版本；然而，非空间版本更难，并且是通过以自我为中心的策略解决的。
