Van Cutsem E, Dicato M, Wils J, Cunningham D, Diaz-Rubio E, Glimelius B, Haller D, Johnston P, Kerr D, Koehne C H, Labianca R, Minsky B, Nordlinger B, Roth A, Rougier P, Schmoll H J
Department Internal Medicine, University Hospital Gasthuisberg, Herestraat 49, 3000, Leuven, Belgium.
Eur J Cancer. 2002 Jul;38(11):1429-36. doi: 10.1016/s0959-8049(02)00122-3.
This article summarises the progress that has been made in the adjuvant treatment of colorectal cancer over the last decade. In view of the consequent improvements in recurrence rates and in overall survival, the development of effective adjuvant treatments for colorectal cancer is considered as one of the most important to be made in clinical oncology over the last decade. Treatment recommendations based on evidence-based data and on expert opinions are summarised in this manuscript. However, a consensus cannot be reached on all aspects of treatment because of data that is currently emerging that will influence clinical practice and because of the many ongoing clinical trials. Those involved in the treatment of colorectal cancer should therefore be encouraged to continue to provide optimal patient care and to participate in well designed clinical trials in order to increase the evidence upon which they can base their clinical judgements and in order to make further progress.
本文总结了过去十年间结直肠癌辅助治疗所取得的进展。鉴于复发率和总生存率随之得到改善,有效的结直肠癌辅助治疗的发展被视为过去十年临床肿瘤学领域最重要的进展之一。本手稿总结了基于循证数据和专家意见的治疗建议。然而,由于目前不断涌现的影响临床实践的数据以及众多正在进行的临床试验,在治疗的所有方面无法达成共识。因此,应鼓励参与结直肠癌治疗的人员继续提供最佳的患者护理,并参与精心设计的临床试验,以增加他们可用于临床判断的证据,并取得进一步进展。