Takahashi Tokiharu, Holland Peter W H, Cohn Martin J, Shimizu Kiyoshi, Kurokawa Mineo, Hirai Hisamaru
School of Animal and Microbial Science, The University of Reading, Whiteknights, Reading, RG6 6AJ, UK.
Dev Genes Evol. 2002 Jul;212(6):293-7. doi: 10.1007/s00427-002-0244-1. Epub 2002 May 24.
We report the cDNA sequence and expression of a mouse homeobox gene, Dmbx1, from the PRD class and comparison to its human orthologue. The gene defines a new homeobox gene family, Dmbx, phylogenetically distinct from the Ptx, Alx, Prx Otx, Gsc, Otp and Pax gene families. The Dmbx1 gene is expressed in the developing mouse diencephalon, midbrain and hindbrain, and has dynamic expression during forelimb and hindlimb development. Unusually for homeobox genes, there is no orthologue in the Drosophila or Caenorhabditis genomes; we argue this reflects secondary loss.
我们报告了一个来自PRD类的小鼠同源异型盒基因Dmbx1的cDNA序列及其表达情况，并将其与其人类直系同源基因进行了比较。该基因定义了一个新的同源异型盒基因家族Dmbx，在系统发育上与Ptx、Alx、Prx、Otx、Gsc、Otp和Pax基因家族不同。Dmbx1基因在发育中的小鼠间脑、中脑和后脑表达，并且在前肢和后肢发育过程中有动态表达。与同源异型盒基因不同的是，在果蝇或秀丽隐杆线虫基因组中没有直系同源基因；我们认为这反映了次生丢失。
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