Tomlinson E, Riley C M, Jefferies T M
J Chromatogr. 1979 May 11;173(1):89-100. doi: 10.1016/s0021-9673(01)80448-9.
The qualitative and quantitative determination of large anionic solutes, including the drug sodium cromoglycate, by an ion-pair high-performance liquid chromatographic technique using alkylbenzyldimethylammonium chlorides as pairing ions is described. The method provides a sensitive and selective assay for the solutes examined in both simple aqueous solutions and in complex biological fluids, and requires no pre-extraction step. Retention mechanisms are discussed.
本文描述了一种离子对高效液相色谱技术，该技术使用烷基苄基二甲基氯化铵作为配对离子，对包括药物色甘酸钠在内的大阴离子溶质进行定性和定量测定。该方法为在简单水溶液和复杂生物流体中检测的溶质提供了灵敏且选择性的分析方法，并且无需预萃取步骤。文中还讨论了保留机制。
