癫痫发作相关的海马体积丢失：颞叶癫痫的纵向磁共振研究

Seizure-associated hippocampal volume loss: a longitudinal magnetic resonance study of temporal lobe epilepsy.

作者信息

Briellmann Regula S, Berkovic Samuel F, Syngeniotis Ari, King Mark A, Jackson Graeme D

机构信息

Brain Research Institute, Department of Neurology, Austin and Repatriation Medical Centre, University of Melbourne, Australia.

出版信息

Ann Neurol. 2002 May;51(5):641-4. doi: 10.1002/ana.10171.

DOI:10.1002/ana.10171

PMID:12112114

Abstract

This longitudinal quantitative magnetic resonance imaging study of 24 patients with mild temporal lobe epilepsy shows an ipsilateral hippocampal volume decrease of 9% (range, -30 to +0.5%; p = 0.002, paired t test) over a period of 3.5 +/- 0.7 years. The hippocampal volume loss was correlated to the number of generalized seizures between the scans (p = 0.0007, r = 0.6), suggesting seizure-associated hippocampal damage.

摘要

这项针对24例轻度颞叶癫痫患者的纵向定量磁共振成像研究显示，在3.5±0.7年的时间里，同侧海马体积减少了9%（范围为-30%至+0.5%；p = 0.002，配对t检验）。海马体积损失与扫描期间全身性癫痫发作的次数相关（p = 0.0007，r = 0.6），提示癫痫发作相关的海马损伤。