Srinivasan K, Ashok M V, Vaz Mario, Yeragani Vikram K
Department of Psychiatry, St. John's Medical College, Bangalore, India.
Depress Anxiety. 2002;15(4):159-67. doi: 10.1002/da.10046.
This study examined the differences of heart rate variability measures between children of parents with panic disorder and children of healthy controls using linear as well as nonlinear techniques. Supine and standing heart rate variability indices were measured in all children using power spectral analysis and a measure of chaos, the largest Lyapunov exponent (LLE) of heart rate time series. No significant differences emerged between the children of panic disorder parents and children of normal controls on any of the spectral heart rate variability measures. However, children of patients with panic disorder had significantly lower LLE of heart rate time series in supine posture, suggesting a relative decrease of cardiac vagal function in this group of children. This suggests a possible heritable effect of certain measures of heart rate variability, as previous studies showed decreased heart rate variability in patients with panic disorder using spectral as well as nonlinear techniques. Recent evidence also suggests that some of these nonlinear measures are superior or of additional value to the traditional time and frequency domain measures of heart rate variability to predict serious ventricular arrhythmias and sudden death.
本研究运用线性及非线性技术，考察了患有惊恐障碍的父母的子女与健康对照者的子女在心率变异性测量方面的差异。使用功率谱分析和一种混沌测量方法，即心率时间序列的最大Lyapunov指数（LLE），对所有儿童测量仰卧位和站立位的心率变异性指标。在任何频谱心率变异性测量中，惊恐障碍父母的子女与正常对照者的子女之间均未出现显著差异。然而，患有惊恐障碍的患者的子女在仰卧位时心率时间序列的LLE显著较低，这表明该组儿童的心脏迷走神经功能相对下降。这表明心率变异性的某些测量可能存在遗传效应，因为先前的研究表明，使用频谱及非线性技术时，惊恐障碍患者的心率变异性降低。最近的证据还表明，这些非线性测量中的一些对于预测严重室性心律失常和猝死而言，优于传统的心率变异性时域和频域测量方法，或具有额外价值。
